Study on the Prevalence of Non-respiratory Comorbidities in Asthma Patients:A Nationwide Cohort Study
10.24304/kjcp.2024.34.3.194
- Author:
Su-Jin KANG
1
;
Kiyon RHEW
Author Information
1. College of Pharmacy, Dongduk Women’s University, Seoul 02748, Republic of Korea
- Publication Type:Original Article
- From:Korean Journal of Clinical Pharmacy
2024;34(3):194-201
- CountryRepublic of Korea
- Language:English
-
Abstract:
Background:Asthma is a chronic inflammatory airway disease associated with systemic inflammation and increased prevalenceof various comorbid conditions. This study investigates the prevalence of non-respiratory comorbidities among adult asthma pa-tients in South Korea, aiming to elucidate potential correlations and impacts of asthma on overall health, thereby affecting patients’quality of life and healthcare systems.
Methods:This retrospective cohort study utilized the National Health Insurance Service data(HIRA-NPS-2020) and included adults diagnosed with asthma. Non-respiratory diseases were identified using the Korean Standard Disease Classification (KCD-8) codes, with exclusions applied for other respiratory conditions. The prevalence of comorbiditieswas analyzed and compared between asthma and non-asthma patients, adjusting for confounders such as age, gender, and insurance status through inverse probability treatment weighting (IPTW).
Results:The analysis revealed that asthma patients exhibit signifi-cantly higher rates of cardiovascular diseases, metabolic disorders, gastrointestinal conditions, and mental health issues compared tothe control group. Notably, conditions such as heart failure, gastroesophageal reflux disease, and anxiety were more prevalent, withodds ratios (OR) ranging from 1.18 to 3.90. These results demonstrate a substantial burden of comorbidities associated with asthma, indicating a broad impact on health beyond the respiratory system.
Conclusion:The findings highlight the systemic nature of asthma and the interconnectedness of inflammatory processes across different organ systems. This comprehensive analysis confirmsprevious research linking asthma with an increased risk of various non-respiratory diseases, providing insights into the multifaceted impact of asthma on patient health.
