A Case of an Ileostomy Patient with Increased Pain after Switching from a Tramadol Rapid Release to an Extended Release Formulation

VernacularTitle:トラマドール速放製剤から徐放製剤への切り替えで疼痛が増強した小腸ストーマ患者の1例
Author: Tomoko SHIRAISHI ¹ ; Asuka IDE ¹ ; Naomi NABESHIMA ¹ ; Reia HASHIMOTO ² ; Megumi KIMURA ¹ ; Arisa FUJII ¹ ; Takako KONDO ¹ ; Kumiko ATAKA ³ ; Junichi TSUKADA ¹
Author Information

1. Palliative Care Center, Hospital of the University of Occupational and Environmental Health
2. Department of Psychiatry, University of Occupational and Environmental Health Fukuoka
3. Nursing Department, Hospital of the University of Occupational and Environmental Health
Keywords: opioid; pharmacokinetics; ileostomy
From:Palliative Care Research 2024;19(4):245-249
CountryJapan
Language:Japanese
Abstract: There are few reports on opioid pharmacokinetics and opioid switching in patients with small intestinal stomas. We experienced a case in which a 40-year-old man with an ileostomy experienced shortened analgesia and increased pain after switching from a fast-release to an extended-release formulation of tramadol. It is possible that the time required for passage through the small intestine and the absorption capacity of the extended-release formulation were insufficient for the extended-release formulation to function effectively, and that more detailed medication adjustment is necessary for patients with small intestinal stomas.