Research Advances on Circular RNA in Malignant Tumors of Digestive System
10.3971/j.issn.1000-8578.2025.24.1330
- VernacularTitle:环状RNA在消化系统恶性肿瘤中的研究进展
- Author:
Yujuan JIANG
1
;
Yantao TIAN
1
Author Information
1. Department of Pancreatic and Gastric Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinses Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:REVIEWS
- Keywords:
Circular RNA;
Malignancies of the digestive system;
Tumorigenesis;
Biomarker;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2025;52(5):418-422
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is involved in tumor suppression or tumor promotion to varying degrees through diverse molecular mechanisms, highlighting its key role in the occurrence and development of tumors. In this review, we systematically summarize the latest research progress on the function and molecular mechanism of circRNA in malignant tumors of the digestive system. circRNA is expected to be further explored as a target molecule in the treatment of digestive system cancers in the future.
