Cancer Immunotherapy and Abnormal Lipid Metabolism
10.3971/j.issn.1000-8578.2025.24.1253
- VernacularTitle:肿瘤免疫治疗与脂质代谢异常
- Author:
Wenxin JIANG
1
;
Peng LIU
1
Author Information
1. Medical Oncology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China.
- Publication Type:SPECIALFEATURE
- Keywords:
Immunotherapy;
Immune checkpoint inhibitors;
Dyslipidemia
- From:
Cancer Research on Prevention and Treatment
2025;52(5):355-360
- CountryChina
- Language:Chinese
-
Abstract:
Lipid metabolism relates to tumor proliferation, progression, and immune escape. With the rapid development of immunotherapy, the relationship between immunotherapy and lipid metabolism has been constantly explored. On the one hand, immunotherapy can cause dyslipidemia and accelerate the progression of atherosclerosis, which has been neglected by clinicians. On the other hand, lipid metabolism can affect antitumor immunity at multiple levels and potentially influence the efficacy of immunotherapy. Lipid metabolism-regulating drugs also have the potential to synergize with immunotherapy. This review summarizes relevant research evidence to inspire further exploration.
