Research progress on the pathophysiological mechanisms of Sirt6 in ophthalmic diseases
10.3980/j.issn.1672-5123.2025.6.14
- VernacularTitle:Sirt6在眼科疾病中的病理生理学机制研究进展
- Author:
Yue LI
1
;
Shengguo LI
1
Author Information
1. Changsha Aier Eye Hospital, Changsha 410015, Hunan Province, China; Aier Academy of Ophthalmology, Central South University, Changsha 410015, Hunan Province, China; Aier Eye Medical Center of Anhui Medical University, Hefei 230022, Anhui Province, China
- Publication Type:Journal Article
- Keywords:
Sirt6;
retina;
inflammation;
apoptosis;
autophagy
- From:
International Eye Science
2025;25(6):946-950
- CountryChina
- Language:Chinese
-
Abstract:
Sirt6(Sirtuin 6), a member of the NAD+-dependent histone deacetylase family, plays a pivotal role in regulating several essential biological processes, including metabolism, DNA repair, anti-oxidative responses, inflammation, and anti-aging. This review synthesizes contemporary insights into Sirt6's pathophysiological mechanisms within major ocular conditions, specifically examining its roles in diabetic retinopathy, age-related macular degeneration, glaucomatous neurodegeneration, and corneal disorders. Studies have demonstrated that Sirt6 significantly influences the onset, progression, and prognosis of ophthalmic diseases through various mechanisms, including the regulation of cellular autophagy, modulation of oxidative stress, suppression of inflammatory responses, and maintenance of mitochondrial function. This review systematically summarizes the latest research advances in the field of Sirt6 in ophthalmic diseases and provides an in-depth analysis of its molecular mechanisms, aiming to offer new theoretical insights and potential therapeutic targets for the prevention and treatment of ophthalmic diseases.
