The effects of Isoorientin on lipopolysaccharide-induced acute lung injury
- VernacularTitle:Липополисахаридаар үүсгэгдсэн уушгины хурц гэмтлийн эмгэг загварт изоориентины үзүүлэх нөлөө
- Author:
Badamjav Rentsen
1
;
Enkhjargal Naranchimeg
1
;
Myagmar Narankhuu
1
;
Batchuluun Tsolmon
1
;
Fang Li
2
Author Information
1. Mongolian University of Pharmaceutical Sciences
2. China Pharmaceutical University, Nanjing, Jiangsu
- Publication Type:Journal Article
- Keywords:
Isoorientin, Lipopolysaccharide, Acute lung injury Inflammation;
Oxidative stress Signaling pathways
- From:
Mongolian Pharmacy and Pharmacology
2024;24(1):50-56
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) usually result in
significant mortality and are featured by pulmonary edema, dysregulated inflammation, and alveolar/capillary
barrier destruction. ALI is derived from various lung injuries such as severe pulmonary infection, near
drowning, lung contusion, and pulmonary embolism.
Methods: This research work was supported by the National Natural Science Foundation of China, Natural
Science Foundation of Jiangsu Province. LPS (from Escherichia coli O55:B5) was purchased from Sigma (St. Louis, MO, USA). Dexamethasone (DEX) was supplied by Shenyang Guangda Pharmaceutical Co., Ltd. The SOD, NO, MPO, and IL-6 assay kits were obtained from Nanjing Jiancheng Bioengineering Institute (Nanjing, China). The identification was performed by Professor Tserendulam Luvsandorj at the Mongolian University of Pharmaceutical Science and specimens were preserved in the School of Traditional Chinese Pharmacy, China Pharmaceutical University. TML was soaked with water for 30 min and decoction three times was conducted with the solid-liquid ratio of 1:10, 1:8, and 1:6, respectively. ICR male mice (8 weeks old, 22–25 g) were purchased from Henan Sikes’s Biotechnology Co., Ltd (Henan, China). Statistical tests were performed using IBM SPSS Statistics version 26.0 Software (SPSS, Inc., Chicago, IL, USA) and presented as mean ± standard deviation for continuous variables.
Conclusion: In summary, the effect of TML on acute lung injury has been studied with Isoorientin, one of its
biologically active compounds. Studies have demonstrated that Isoorientin has been shown to protect against pulmonary edema, inflammatory cells, and inflammatory cytokine mediator expression in acute lung injury caused by LPS. Therefore, we have a certain need to study the mechanisms by which this protective effect takes place further.
- Full text:202505110145167600MPPJ-2024-24(1)-50-56.pdf
