Immune effect of inactivated foot-and-mouth disease vaccine combined with goat pox vaccine and live Brucella vaccine
10.13200/j.cnki.cjb.004455
- VernacularTitle:牛口蹄疫灭活疫苗、山羊痘活疫苗、布氏菌活疫苗联合使用的免疫效果分析
- Author:
LI Xiaozhuo
- Publication Type:Journal Article
- Keywords:
Calf;
Inactivated foot-and-mouth disease vaccine(IFMDV);
Goat pox vaccine(GPV);
Live Brucella vaccine(LBV);
Combined immunization
- From:
Chinese Journal of Biologicals
2025;38(04):392-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the immune effect of combined use of inactivated foot-and-mouth disease vaccine(IFMDV),goat pox vaccine(GPV) and live Brucella vaccine(LBV), and to provide a new and efficient immunization model for the prevention and treatment of bovine diseases in China.Methods Twenty healthy calves were immunized with IFMDV and GPV to observe the adverse reactions after immunization. The antibody levels against foot-and-mouth disease and bovine nodular skin disease in serum were determined by liquid phase blocking ELISA and competitive ELISA respectively. Twenty healthy calves were immunized with IFMDV and LBV to observe the adverse reactions after immunization, and the serum antibody levels against foot-and-mouth disease and Brucella were determined by liquid phase blocking ELISA and tube agglutination test respectively. Finally, IFMDV, LBV and GPV were combined to immunize twenty healthy calves, and the adverse reactions of the immunized calves were observed. The serum antibody levels against foot-and-mouth disease,Brucella and bovine nodular skin disease were determined by liquid phase blocking ELISA, tube agglutination test and competitive ELISA respectively.Results No serious adverse reactions were observed in IFMDV combined with GPV or LBV immunized calves. The level of GPV antibody in serum of calves immunized with IFMDV and GPV at the same time was significantly higher than that of calves immunized with GPV alone. The level of LBV antibody in serum of calves immunized with IFMDV and LBV at the same time was higher than that of calves immunized with LBV alone. In the combined immunization group with IFMDV, GPV and LBV, the antibody levels of GPV and LBV in serum of calves were both higher than those of calves with single immunization.Conclusion IFMDV combined with GPV and LBV has good safety, and can improve the immune effect of GPV and LBV.
