Establishment and application of evaluation criteria for rational use of pyrotinib
- VernacularTitle:吡咯替尼临床合理用药评价标准的建立与应用
- Author:
Yiyi LIAO
1
;
Xin LI
2
;
Yaowen XIA
3
;
Hongmei ZHAO
1
;
Qingqing CHEN
4
Author Information
1. Dept. of Clinical Pharmacy，Hainan Cancer Hospital，Haikou 570100，China
2. Dept. of Pharmacy，Hainan Health Vocational College，Haikou 570100，China
3. Dept. of Pharmacy，Guangdong Province Hospital of Chinese Medicine，Hainan Hospital，Haikou 570100，China
4. Dept. of Pharmacy，Hainan West Central Hospital，Hainan Danzhou 571700，China
- Publication Type:Journal Article
- Keywords:
pyrotinib;
AHM;
EWM;
weighted TOPSIS
- From:
China Pharmacy
2025;36(6):742-747
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish drug utilization evaluation （DUE） criteria for pyrotinib to promote its appropriate application in clinical practice. METHODS Based on the label of Pyrotinib maleate tablets， with relevant guiding principles and diagnostic and treatment guidelines as the evaluation basis， DUE criteria for pyrotinib were determined through the Delphi method. Attribute hierarchical model （AHM） and entropy weight method （EWM） were used to combine and assign weights to each indicator within the DUE criteria. Additionally， the weighted technique for order preference by similarity to an ideal solution （TOPSIS） method was applied to perform rationality evaluation of medication in archived medical records from Hainan Provincial Tumor Hospital and Hainan Western Central Hospital regarding the use of pyrotinib from November 2019 to November 2023. RESULTS The established DUE criteria for pyrotinib included 4 primary indicators （prescription authority， indications for use， medication process， and medication outcomes） and 11 secondary indicators. The secondary indicators with higher weights were the route of administration and dosage （0.257） and indications in the label （0.241）. Among the 88 archived cases included， there were 28 cases of inappropriate medication （31.82%）， 43 cases of generally appropriate medication （48.86%）， and 17 cases of appropriate medication （19.32%）. The main issues related to inappropriate medication involved off-label use （42.05%） and inappropriate routes of administration and dosage （43.18%）. CONCLUSIONS DUE criteria for pyrotinib established using the AHM-EWM-weighted TOPSIS method is highly operational and results in quantifiable evaluation outcomes. The overall rationality of the use of pyrotinib in the above hospitals remains to be improved， and there are some issues， like the off-label use，and inappropriate routes of administration and dosage being liaoyylyy@163.com unreasonable.
