Research progress on the structural modification of isosteviol and the biological activities of its derivatives
10.16438/j.0513-4870.2024-0491
- VernacularTitle:异斯特维醇的结构修饰及其衍生物的生物活性研究进展
- Author:
Li-jun ZHAO
1
;
You-fu YANG
1
;
Tong-sheng WANG
1
;
Yan-li ZHANG
2
;
Ya WU
2
Author Information
1. College of Medicine, Henan University of Chinese Medicine, Zhengzhou
2. College of Medicine, Henan University of Chinese Medicine, Zhengzhou; The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou
- Publication Type:Research Article
- Keywords:
isosteviol;
erivative;
structural modification;
microbial transformation;
biological activity;
structure-activity relationship
- From:
Acta Pharmaceutica Sinica
2025;60(1):22-36
- CountryChina
- Language:Chinese
-
Abstract:
Isosteviol is a tetracyclic diterpenoid compound obtained by hydrolysis of natural stevia glycoside under acidic conditions. It has many pharmacological activities, such as anti-tumor, hypoglycemic, anti-inflammatory and antibacterial. Due to its low water solubility, low activity and low bioavailability, isosteviol has poor performance. In order to overcome these shortcomings, scholars have obtained a large number of isosteviol derivatives with novel structures and excellent activity. In this paper, we review the recent progress in the research on the structure modification, biological activity, structure-activity relationship and microbial transformation of isosteviol, in order to provide a reference for the development of new drugs of isosteviol and its derivatives.
