Two new diphenyl ethers from the whole plant of <italic>Canscora lucidissima</italic>

Meng-yu ZHANG; Jiao LIU; Chang LIU; Tao ZHANG; Zhong-mei ZOU

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Two new diphenyl ethers from the whole plant of Canscora lucidissima

VernacularTitle:穿心草全草中两个新的二苯醚类化合物
Author: Meng-yu ZHANG ¹ ; Jiao LIU ² ; Chang LIU ¹ ; Tao ZHANG ³ ; Zhong-mei ZOU ¹
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1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
2. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
Publication Type:Research Article
Keywords: Gentiaceae; italic>Canscora lucidissima; chemical constituent; iphenyl ether; anti-inflammatory effect
From: Acta Pharmaceutica Sinica 2024;59(12):3335-3341
CountryChina
Language:Chinese
Abstract: Twelve compounds were isolated and purified from 95% ethanol extract of the whole plant of C. lucidissima by silica gel column chromatography, MCI column chromatography and ODS column chromatography, polyamide column chromatography, Sephadex LH-20 column chromatography, combined with semi-preparative HPLC methods. Based on the physicochemical properties and spectral data (UV, IR, MS, NMR), the structures of the isolates were identified as canlucdiphenyl ether A (1), canlucdiphenyl ether B (2), canlucbenzophenone A (3), (-)-pinoresinol (4), 3-hydroxybenzoic acid (5), 1,3,8-trihydroxy-6-hydroxymethylanthraquinone (6), dihydrokaempferol (7), 6,7-dihydroxycoumarin (8), 4-hydroxy-3,5-dimethoxybenzoic acid (9), 4-hydroxy-3,5-dimethoxycinnamic acid (10), 2-hydroxy-3-methoxybenzoic acid (11), (-)-syringaresinol (12). Among them, compounds 1 and 2 are two new diphenyl ether and 3 is a new natural product. Compound 8 exhibited some anti-inflammatory activity by inhibiting the lipopolysaccharide-induced NO production in RAW264.7 cells.