Research progress of chitosan-based materials applied in oral mucosal drug delivery systems
10.16438/j.0513-4870.2024-0616
- VernacularTitle:壳聚糖基材料应用于口腔黏膜给药系统的研究进展
- Author:
Rui-kai ZHU
1
;
Kai-dian YANG
2
;
Kai ZHAO
3
Author Information
1. Ministry of Education & Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region, Engineering Research Center of Agricultural Microbiology Technology, School of Life Sciences, Heilongjiang University, Harbin
2. Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou
3. Ministry of Education & Heilongjiang Provincial Key Laboratory of Plant Genetic Engineering and Biological Fermentation Engineering for Cold Region, Engineering Research Center of Agricultural Microbiology Technology, School of Life Sciences, Heilongjiang University, Harbin; Taizhou Key Laboratory of Biomedicine and Advanced Dosage Forms, School of Life Sciences, Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation, Taizhou University, Taizhou
- Publication Type:Research Article
- Keywords:
chitosan-based material;
oral mucosal drug delivery system;
chitosan and its derivative;
first pass barrier effect;
nanopreparation
- From:
Acta Pharmaceutica Sinica
2024;59(12):3232-3241
- CountryChina
- Language:Chinese
-
Abstract:
Administration oral mucosal drug delivery has the advantages of high patient acceptance, rapid onset of action, convenient, etc., and it can avoid the first-pass effect of the drug in the liver. Nevertheless, the design of oral mucosal drug delivery systems is inherently challenging due to the distinctive physicochemical properties of certain drugs and the specific physiological environment of the oral cavity. Natural polysaccharide chitosan-based materials exhibit favorable characteristics, including non-toxicity or low toxicity and biodegradability. These materials can effectively inhibit bacterial growth, enable controlled drug release, and enhance mucosal adhesion. Consequently, chitosan-based materials have been the subject of extensive research in the field of oral mucosal drug delivery systems. This paper offers a comprehensive overview of oral mucosal drug delivery systems, reviews relevant studies on chitosan-based materials, and discusses future prospects for their application.
