Advances and clinical transformation of microsphere drug delivery systems
10.16438/j.0513-4870.2024-0380
- VernacularTitle:微球载药系统的前沿进展和临床转化
- Author:
Qi-long WU
1
;
Wen-yue LAN
2
;
Ming-jie CUI
3
;
Jun-jue WANG
1
;
Wen-hao CHENG
4
;
Hai-jun YU
5
Author Information
1. Nanjing University of Chinese Medicine, Nanjing; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai
2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai; University of Chinese Academy of Sciences, Beijing
3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai; Shenyang Pharmaceutical University, Shenyang
4. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai
5. Nanjing University of Chinese Medicine, Nanjing; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai; Shenyang Pharmaceutical University, Shenyang; University of Chinese Academy of Sciences, Beijing
- Publication Type:Research Article
- Keywords:
microsphere drug delivery system;
fabrication method;
localized drug delivery;
rug deposit;
clinical translation
- From:
Acta Pharmaceutica Sinica
2024;59(12):3242-3250
- CountryChina
- Language:Chinese
-
Abstract:
The microsphere drug delivery systems have been extensively exploited for providing controllable drug release kinetics, enhancing drug stability and localized drug delivery. In past decade, dozens of microsphere drug delivery systems have been developed for clinical therapy of cancer, schizophrenia and neurodegenerative diseases (e.g., Alzheimer's disease and Parkinsonism). In this review article, we comprehensively summarized the fabrication methods of drug delivery systems and highlighted their advances for clinical application. Furthermore, we analyzed the potential and the challenges for clinical translation of the drug delivery systems.
