Advances in the application of photoacoustic microscopy imaging in ophthalmology
10.3980/j.issn.1672-5123.2025.4.15
- VernacularTitle:光声显微成像技术在眼科的应用进展
- Author:
Chu LIU
1
;
Zhengwei ZHANG
1
Author Information
1. Jiangnan University Medical Center;Wuxi No.2 People's Hospital, Wuxi 214002, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
photoacoustic microscopy;
ocular disease;
diagnosis;
evaluation;
application
- From:
International Eye Science
2025;25(4):606-610
- CountryChina
- Language:Chinese
-
Abstract:
Photoacoustic microscopy(PAM)is an emerging, non-invasive, in vivo imaging modality that merges optical and acoustic principles. It offers high-resolution and high-contrast visualization of various ocular tissue structures and functional information, making it suitable for studying a wide range of ophthalmic diseases such as corneal neovascularization, macular degeneration, and diabetic retinopathy. The multi-wavelength illumination capability of PAM makes it particularly valuable for early disease screening and dynamic physiological monitoring. In stem cell tracking, PAM enables the dynamic monitoring of transplanted cells through contrast agent labeling. Moreover, when combined with multimodal imaging techniques like optical coherence tomography(OCT), PAM can enhance the detection accuracy and diagnostic capacity for ocular diseases. However, PAM still requires optimization in terms of imaging speed and contrast agent safety. This review summarizes the fundamental principles and development of PAM, explores its applications in specific ophthalmic diseases, and analyzes the challenges and optimization directions from animal experiments to clinical applications. PAM holds great promise for playing a more significant role in ophthalmic diagnosis and treatment.
