Advancement of corneal cross-linking therapy in non-expanding corneal lesions

VernacularTitle:角膜交联疗法在非扩张性角膜病变中的应用研究进展
Author: Jing WU ¹ ; Jingfa ZHANG ¹
Author Information

1. Tongren Hospital;Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China; Xishan Coal Electricity Corporation Occupational Disease Prevention and Control Institute, Taiyuan 030027, Shanxi Province, China
Publication Type:Journal Article
Keywords: corneal cross-linking; riboflavin; ultraviolet radiation; corneal diseases
From: International Eye Science 2025;25(4):573-576
CountryChina
Language:Chinese
Abstract: In recent years, with the development of corneal cross-linking technology, corneal cross-linking therapy combined with adopting riboflavin and ultraviolet has been widely used in several corneal disorders, not only for keratoconus, but also for other corneal diseases, including infectious keratitis,chemical corneal injury, bullous keratopathy, and refractive surgery. Corneal cross-linking is a non-invasive procedure with the virtue of minor damage, rapid rehabilitation, convenient operation, and high safety. This review aims to investigate the mechanism of corneal cross-linking therapy, emphasizing the new progress of its efficacy and safety in the application of treating non-expanding corneal diseases, including infectious keratitis, chemical burns, bullous keratopathy and marginal degeneration. Corneal cross-linking therapy may be potentially helpful in the treatment of non-expanding corneal diseases.