Multi-source Fusion Analysis and Medication Pattern Mining of Clinical Literature on Traditional Chinese Medicine Treatment of Gout
10.13422/j.cnki.syfjx.20241613
- VernacularTitle:中医药治疗痛风的临床文献多源融合分析与用药规律挖掘
- Author:
Ao ZHANG
1
;
Xiaoqian WANG
1
Author Information
1. Zhejiang Chinese Medical University， Hangzhou 310053， China
- Publication Type:Journal Article
- Keywords:
gout;
syndrome of dampness-heat accumulation;
traditional Chinese medicine inheritance support system;
medication pattern;
Coicis Semen
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(8):244-249
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo perform a multi-source data fusion analysis of the clinical literature on traditional Chinese medicine （TCM） treatment of gout， explore the front hotspots in this field， and mine the clinical consensus and medication patterns in the TCM treatment of gout with the syndrome of dampness-heat accumulation， thus providing reference for the standardized treatment of this disease. MethodsCNKI， Wanfang， and VIP were searched for the relevant literature. COOC14.9/VOSviewer was used to perform multi-source data fusion analysis of clinical literature on the TCM treatment of gout and construct a visual knowledge map for exploring the research hotspots and frontiers of the TCM treatment of gout. The Traditional Chinese Medicine Inheritance Support System （V3.0） was used to establish the database of TCM treatment of gout with the syndrome of dampness-heat accumulation and explore the medication pattern and prescription characteristics. ResultsThe number of published clinical articles on the TCM treatment of gout has remained high. The research hotspots included comparative studies on the etiology and pathogenesis of gout， identification and typing， prescription composition， and clinical efficacy. A large amount of data has been accumulated in the medicine use experience and the summarization of therapeutic effects. The medication patterns in the TCM treatment of gout with the syndrome of dampness-heat accumulation were mined from the articles that were published during 2019-2023. It was revealed that clinically used drugs can be categorized into 9 groups according to their efficacy. Among them， the drugs with the effects of promoting urination and draining dampness were the richest and had the highest frequency. Meanwhile， the drugs with the effects of resolving dampness and expelling wind-dampness were also commonly used in clinical practice. The combined use of drugs with effects of eliminating dampness， resolving dampness， and expelling dampness plays a key role in the treatment of gout with the syndrome of dampness-heat accumulation. Secondly， heat-clearing drugs are also commonly used， with the types and frequency close to those of urination-promoting and dampness-draining drugs. In addition， drugs with the effects of activating blood and eliminating stasis are commonly prescribed. The prescriptions modified from Simiaowan were commonly used， and the most commonly used drug was Coicis Semen. The analysis of drug combination applications and core drug combinations showed that the core drugs used in the treatment of gout with the syndrome of dampness-heat accumulation were Coicis Semen， Phellodendri Chinensis Cortex， Atractylodis Rhizoma， Achyranthis Bidentatae Radix， Smilacis Glabrae Rhizoma， Dioscoreae Hypoglaucae Rhizoma， Alismatis Rhizoma， and Clematidis Radix et Rhizoma， which were closely related. Coicis Semen was an assistant and guide drug in Simiaowan， while it was the most commonly used in the treatment of gout with the syndrome of dampness-heat accumulation. ConclusionsClinical studies on the TCM treatment of gout are in-depth and diverse， and the core medicinal combination was essentially modified Simiaowan. Coicis Semen， with the highest frequency， has a special efficacy in the treatment of gout with the syndrome of dampness-heat accumulation and is worthy of further in-depth study.
