Research Progress on Pathogenesis of Diabetic Kidney Disease Based on Ferroptosis and Intervention of Traditional Chinese Medicine
10.19378/j.issn.1003-9783.2024.06.018
- VernacularTitle:基于铁死亡的糖尿病肾病发病机制及中药干预的研究进展
- Author:
Lihui FAN
1
;
Zhigang WANG
;
Xia YANG
;
Kun ZHANG
;
Xiaolong MEI
Author Information
1. 甘肃中医药大学中医临床学院,甘肃 兰州 730000
- Keywords:
Ferroptosis;
diabetic kidney disease;
mechanism;
traditional Chinese medicine formula;
active ingredients
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(6):917-927
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease(DKD)is the leading cause of end-stage renal disease worldwide and one of the major microvascular complications of diabetes.The pathogenesis of DKD is multifactorial,and its pathological process involves multiple pathways.Ferroptosis is a regulatory cell death characterized by iron dependent lipid peroxidation.Recently,an increasing number of studies have shown that ferroptosis is a key driving factor for the occurrence and development of DKD and has been identified to play a crucial role in the occurrence,development,and treatment of various kidney diseases.Traditional Chinese medicine has unique advantages in preventing and delaying the progression of DKD due to the characteristics of multi-component,multi-target,and multi-pathway.This article focuses on summarizing the impact of key regulatory factors and signaling pathways of ferroptosis on the pathological process of DKD,as well as the research progress of traditional Chinese medicine in regulating ferroptosis key factors and pathways for preventing and treating DKD.The aim of this study is to provide new ideas for the clinical treatment of DKD and the development of new traditional Chinese medicine drugs.
