Identification of links between excessive daytime sleepiness and gut microbiota using Mendelian randomization analysis
10.3969/j.issn.1673-9701.2024.31.007
- VernacularTitle:利用孟德尔随机化分析日间过度思睡人群肠道菌群特点
- Author:
Hong ZHANG
1
;
Lin HUA
Author Information
1. 清华大学临床医学院/清华大学附属北京清华长庚医院耳鼻咽喉头颈外科,北京 102218
- Keywords:
Excessive daytime sleepiness;
Gut microbiota;
Brain-gut axis;
Single nucleotide polymorphism;
Mendelian randomization
- From:
China Modern Doctor
2024;62(31):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of gut microbiota in excessive daytime sleepiness(EDS).Methods Two-sample Mendelian randomization(MR)analysis was performed using genome-wide association study(GWAS)data,with gut microbiota as an exposure factor,EDS as an outcome factor,and single nucleotide polymorphism(SNP)as an instrumental variable,and a variety of methods were used to screen potential pathogenic gut microbes for EDS.The robustness of the results of MR analysis was ensured by using different sensitivity analyses.Results Based on the results of the multiple analyses,abundances of Butyricimonas,Peptococcus,Bilophila,Anaerofilum,Ruminococcus gnavus and Coprococcus were higher in EDS population,while abundances of Oscillospira and Desulfovibrio were relatively lower.Conclusion There was an imbalance of gut microbiota in EDS people,and whether adjusting gut microbiota structure by changing diet structure and using probiotics can improve EDS remains to be confirmed by further studies in the future.
