The effect of recombinant human prourokinase on without reflow or slow blood flow during emergency percutaneous coronary intervention in patients with acute inferior ST segment elevation myocardial infarction
10.3969/j.issn.1673-9701.2024.30.016
- VernacularTitle:重组人尿激酶原对急性下壁ST段抬高心肌梗死患者急诊经皮冠脉介入术中无复流或慢血流的影响
- Author:
Fang WANG
1
;
Long MA
;
Yangyang HE
;
Hao FENG
;
Xiaotong ZHU
;
Hui YONG
Author Information
1. 新沂市人民医院心血管内科病区(一),江苏新沂 221400
- Keywords:
Recombinant human prourokinase;
Infarction related artery;
Percutaneous coronary intervention;
Thrombolysis in myocardial infarction blood flow grading method
- From:
China Modern Doctor
2024;62(30):79-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical efficacy of recombinant human prourokinase during emergency coronary intervention (PCI) in patients with acute inferior wall ST segment elevation myocardial infarction (STEMI) without reflow or slow blood flow.Methods Eighty patients with acute inferior wall STEMI admitted to Xinyi People's Hospital from January 2022 to December 2023 were selected.The patients were divided into two groups,40 cases in each group.The control group patients accepted PCI after receiving 100μg nitroglycerin or nitroprusside via catheter;On the basis of control group,the observation group patients received 20mg recombinant human prourokinase via catheter until infarct related artery,and PCI was performed.Using thrombolysis in myocardial infarction (TIMI) blood flow grading method,compared the immediate myocardial perfusion after surgery.Results Comparison of immediate TIMI blood flow grading between two groups of patients during surgery,with grades ranging from level 0 to 1:1 case (2.5％) in observation group and 7 cases (17.5％) in control group.The difference between two groups was statistically significant (P<0.05);Level 2:3 cases (7.5％) in observation group and 8 cases (20.0％) in control group.There was no statistically significant difference between two groups (P>0.05);Level 3:36 cases (90.0％) in observation group and 25 cases (62.5％) in control group.The difference between two groups was statistically significant (P<0.05).Conclusion Recombinant human prourokinase can effectively improve the coronary blood flow of infarct related artery during emergency PCI in patients with acute inferior wall STEMI,improve myocardial ischemia,and do not increase adverse reactions such as bleeding,which is of great significance for improving patient's prognosis.
