Effect of whey protein supplementation on stroke-related sarcopenia in patients with diabetes mellitus
10.3969/j.issn.1673-9701.2024.22.007
- VernacularTitle:补充乳清蛋白对合并糖尿病的脑卒中相关肌少症患者的影响
- Author:
Lili SU
1
;
Xiaoyang FANG
;
Ling LIN
;
Haiyan LI
Author Information
1. 温州医科大学附属第一医院康复科,浙江温州 325000
- Keywords:
Sarcopenia;
Whey protein;
Nutritional intervention;
Stroke;
Diabetes mellitus
- From:
China Modern Doctor
2024;62(22):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of whey protein supplementation on rehabilitation of stroke-related sarcopenia patients with diabetes mellitus.Methods Forty-seven stroke-related sarcopenia patients with diabetes mellitus admitted to the First Affiliated Hospital of Wenzhou Medical University from January 2021 to September 2023 were selected and divided into observation group(24 cases)and control group(23 cases)according to random number table method.Patients in both groups were given normal diabetic diet,conventional drug therapy and rehabilitation training,and patients in observation group were given whey protein powder orally every day for 4 weeks.The non-hemiplegic hand grip strength,appendicular skeletal muscle mass index(ASMI),modified Barthel index(MBI),Fugl-Meyer assessment(FMA),mini-nutritional assessment short-form(MNA-SF),serum albumin(Alb),C-reactive protein(CRP)were compared between two groups before and after intervention.Results After intervention,the grip strength,ASMI,FMA,MBI of two groups were significantly higher than before ntervention,and CRP level was significantly lower than before intervention(P<0.05).The grip strength,ASMI,FMA,MBI,MNA-SF score and Alb of observation group were significantly higher than those of control group,while CRP was significantly lower than that of control group(P<0.05).ASMI was positively correlated with Alb,MNA-SF score and grip strength(P<0.05),while CRP was negatively correlated with Alb,MNA-SF score and ASMI(P<0.05).Conclusion Supplementation of whey protein can improve the nutritional status,muscle strength and muscle mass of patients with stroke-related sarcopenia complicated with diabetes mellitus,and improve the physical motor function and the ability of daily living.
