Correlation and clinical value of estradiol,blood lipids and clinicopathological characteristics of postmenopausal ischemic stroke
10.3969/j.issn.1673-9701.2024.20.008
- VernacularTitle:雌二醇、血脂与绝经后缺血性脑卒中临床病理特征的相关性及临床价值
- Author:
Min ZHANG
1
;
Dan ZHANG
;
Xiao SHEN
Author Information
1. 湖州市第一人民医院神经内科,浙江湖州 313000
- Keywords:
Ischemic stroke;
Estradiol;
Blood lipids;
Menopause;
Clinical value
- From:
China Modern Doctor
2024;62(20):35-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation and clinical value of serum estradiol(E2)and blood lipids with the clinicopathological characteristics of postmenopausal ischemic stroke(IS).Methods Totally 90 postmenopausal IS patients(ICS group)and normal healthy people(control group)from January 2019 to January 2020 were selected as the research subjects,and the serum E2,blood lipids,National Institutes of Health Stroke Scale(NIHSS)score,modified Barthel index(MBI)and Fug-Meyer assessment scale(FMA)score,S100 calcium binding protein B(S100B),myelin basic protein(MBP)and Tau protein were compared.Pearson correlation analysis analyzed the correlation between serum E2,blood lipids and NIHSS score,MBI score,FMA score,S100B,MBP,and Tau protein.The receiver operating characteristic curve was used to analyze the effectiveness of detection indicators in predicting 1-year mortality in postmenopausal IS patients.Logistics regression analysis of risk factors for 1-year death in postmenstrual IS patients.Results The serum E2,high-density lipoprotein cholesterol(HDL-C),MBI scores,and Tau protein FMA scores of the subjects in the ICS group were all significantly lower than those in the CON group,and total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),NIHSS scores,S100B,and MBP were all significantly higher than those in the control group,and the differences were statistically significant(All P＜0.05).E2 and high-density lipoprotein cholesterol,HDL-C in postmenopausal IS patients were negatively correlated with NIHSS score,S100B,and MBP(P＜0.05),and positively correlated with MBI score,FMA score,and Tau protein(P＜0.05).TC,TG,and LDL-C were positively correlated with NIHSS score,S100B,and MBP(P＜0.05),and negatively correlated with MBI score,FMA score,and Tau protein(P＜0.05).The cutoff value of E2 for predicting 1-year death from postmenopausal stroke is 31.2pg/ml,with a sensitivity of 71.9％and a specificity of 87.8％.The cutoff value of TC for predicting 1-year death from postmenopausal stroke is 7.3mmol/L,the sensitivity is 61.0％,and the specificity is 83.7％.The cutoff value of TG for predicting 1-year death from postmenopausal stroke is 2.4mmol/L,with a sensitivity of 61.2％and a specificity of 89.8％.The cutoff value of LDL-C for predicting 1-year death from postmenopausal stroke is 4.7mmol/L,with a sensitivity of 63.3％and a specificity of 83.7％.The cutoff value of HDL-C for predicting 1-year death from postmenopausal stroke is 0.5mmol/L,the sensitivity is 72.2％,and the specificity is 85.5％.E2≤31.2pg/ml,TC＞7.3mmol/L,TG＞2.4mmol/L,LDL-C＞4.7mmol/L,HDL-C≤0.5mmol/L are risk factors for 1-year death in postmenopausal IS patients(P＜0.05).Conclusion Serum E2 and HDL-C in postmenopausal IS patients are significantly reduced,and TC,TG and LDL-C are significantly increased,which are closely related to neurological damage and 1-year death events,and have important value in predicting 1-year death in postmenopausal IS.
