Clinical study on treating diabetic nephropathy by flexible using Guizhi Fuling pill and Siwei Jianbu decoction
10.3969/j.issn.1673-9701.2024.16.023
- VernacularTitle:桂枝茯苓丸合四味健步汤加味治疗糖尿病肾病的临床研究
- Author:
Suzhen LIN
1
;
Yu CHEN
Author Information
1. 浙江中医药大学附属温州市中医院肾病科,浙江温州 325000
- Keywords:
Guizhi Fuling pill;
Siwei Jianbu decoction;
Diabetic nephropathy;
Syndrome of intermin-gled water and blood stasis;
Inflammatory reaction;
Hypercoagulabale state
- From:
China Modern Doctor
2024;62(16):98-101,118
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of flexible using Guizhi Fuling pill and Siwei Jianbu decoction in treating the diabetic nephropathy patients,and to observe its effect on inflammatory indicators and hypercoagulabale state.Methods A total of 78 patients diagnosed with syndrome of intermin-gled water and blood stasis diabetic nephropathy in Wenzhou TCM Hospital of Zhejiang Chinese Medical University from January to December 2022 were selected and divided into observation group and control group by random number table method,with 39 cases in each group.The control group was treated with conventional western comprehensive therapy,while the observation group was treated with Guizhi Fuling pill and Siwei Jianbu decoction on the basis of control group.Both groups were treated for 8 weeks.The TCM syndrome score,24h urinary protein quantity,serum creatinine(SCr),blood urea nitrogen(BUN),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),fibrinogen,D-dimer,alanine aminotransferase(ALT),aspartate aminotransferase(AST)were compared between two groups before and after treatment.Results After treatment,the TCM syndrome score,24h urinary protein quantity,SCr,BUN,IL-6,TNF-α,fibrinogen and D-dimer in two groups were significantly lower than before treatment(P<0.05).The TCM syndrome score,24h urinary protein quantity,SCr,IL-6,TNF-α,fibrinogen and D-dimer in observation group were significantly lower than those in control group(P<0.05).The total effective rate of observation group was significantly higher than that of control group(χ2=6.241,P=0.044).There was no adverse reaction between two groups after treatment,and there was no significant difference in liver function indexes before and after treatment(P>0.05).Conclusion Flexible using Guizhi Fuling pill and Siwei Jianbu decoction has a good therapeutic effect on syndrome of intermin-gled water and blood stasis diabetic nephropathy,which can reduce clinical symptoms of patients,reduce 24h urinary protein quantity and improve renal function,which is speculated to be related to reducing inflammation and improving hypercoagulabale state.
