Efficacy and safety of skin care products containing mandelic acid and niacinamide in adjunctive treatment of mild to moderate acne
10.3760/cma.j.issn.1671-0290.2024.05.016
- VernacularTitle:含有杏仁酸及烟酰胺的护肤品辅助治疗轻中度痤疮的疗效及安全性分析
- Author:
Qian ZHANG
1
;
Yuanli WANG
;
Huan JING
;
Kai LI
Author Information
1. 空军军医大学西京医院皮肤科，西安 710032
- Keywords:
Acne vulgaris;
Mandelic acid;
Niacinamide;
Skin barrier function;
Adverse reaction
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2024;30(5):494-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the efficacy and safety of skin care products containing mandelic acid and niacinamide in the management of mild to moderate acne.Methods:A total of 50 patients with mild to moderate acne were prospectively enrolled at Xijing Hospital, Air Force Military Medical University, from June to October 2020. Participants were randomly assigned into an observation group and a control group using a random number table method, with each group comprising 25 individuals. The observation group consisted of 3 males and 22 females, with a mean age of (22.5±3.2) years; the control group also included 3 males and 22 females, with a mean age of (22.9±2.8) years. The control group received conventional acne treatment without any additional skin care interventions apart from daily facial cleaning; conversely, the observation group was treated with skin care products containing mandelic acid and niacinamide alongside standard treatment protocols. At weeks 2, 4, and 8 post-treatment, objective assessments utilizing skin property system and VISIA complexion analysis system were conducted to evaluate changes in lesion count as well as recovery of skin barrier function between both groups; additionally, patients completed adverse reaction record forms.Results:No significant differences were observed regarding gender distribution, age demographics, disease duration or severity between the two groups ( P>0.05). After 8 weeks of treatment, the rates of effective improvement for skin lesions and acne were observed to be 84.0% (21/25) in the observation group compared to 56.0% (14/25) in the control group for lesion improvement, and 84.0% (21/25) versus 44.0% (11/25) for acne improvement, respectively. When compared to the control group, the observation group demonstrated significantly higher rates of effective improvement in both skin lesions and acne ( P<0.001).VISIA analysis revealed that pore size scores as well as violet scores decreased significantly after eight weeks in comparison to controls ( P=0.035; P=0.027). CK results indicated reduced transepidermal water loss along with diminished sebum levels within the observation cohort relative to controls ( P=0.009; P=0.042). Skin erythema along with symptoms such as dryness or burning sensations occurred among five patients (three from the observation cohort while two belonged to controls) with no serious adverse reactions reported across either study arm. Conclusions:Skin care products incorporating mandelic acid and niacinamide can serve effectively as adjunctive treatments for mild-to-moderate acne with enhancing clinical outcomes accompanied by minimal adverse effects.
