Pathogen distribution and drug resistance characteristics of skin and soft tissue infection
10.3760/cma.j.issn.1671-0290.2024.05.010
- VernacularTitle:皮肤软组织感染病原菌分布及耐药特征分析
- Author:
Yao MA
1
;
Chenglong FEI
Author Information
1. 杭州米兰柏羽美容医院美容皮肤科，杭州 310001
- Keywords:
Skin;
Soft tissue infection;
Pathogenic bacteria;
Drug resistance
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2024;30(5):466-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution of pathogens and resistance to commonly used antimicrobial drugs in patients with skin and soft tissue infection.Methods:It was a cross-sectional study from April 2020 to April 2021, 120 patients with skin and soft tissue infection, including 65 males and 55 females, aged 21 to 64 (44.4±3.2) years. The wound pus or secretion samples were collected for inspection and bacterial isolation and identification and drug susceptibility test to observe the distribution of pathogens and resistance to commonly used antimicrobial drugs.Results:A total of 140 pathogens were isolated from 120 patients with skin and soft tissue infection, including 76 Gram (54.29%) positive, 51 Gram (36.43%) negative bacteria and 13 fungus (9.29%). In terms of bacterial resistance, the three main Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus haemolyticus had high rates of drug resistance: 71.05% Staphylococcus aureus were resistance to ampicillin/sulbactam; 63.16 to erythromycin, and 42.11 to ampicillin/sulbactam; S. epidermidis showed 100% resistant to penicillin, 57.89% to erythromycin, and 47.37% to ampicillin/sulbactam; the resistance of Staphylococcus haemolyticus was 70% to penicillin, 50% to erythromycin, 50% to ampicillin/sulbactam; Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus showed low resistance to nitrofurantoin, linezolid, and vancomycin. S. aureus showed 0% resistance to nitrofurantoin, 0% to linecolamine, and 0% to vancomycin. Staphylococcus epidermidis was 0% resistant to nitrofurantoin and 15.79% resistant to linezolid; S. haemolyticus showed 0% resistance to nitrofurantoin, linecolamine and vancomycin. Three main Gram-negative bacteria, Escherichia coli, Pseudomonas aeruginosa, and K. pneumoniae, showed high resistance to erythromycin, ciprofloxacin, ofloxacin, and gentamicin. E. coli showed 80% resistance to erythromycin, 64% to ciprofloxacin, 60% to ofloxacin, and 52% to gentamicin. P. aeruginosa showed 46.15% resistance to erythromycin, 46.15 to ciprofloxacin, 38.46% to ofloxacin, and 38.46% to gentamicin. Klebsiella pneumoniae showed resistance to erythromycin (57.14%), ciprofloxacin (42.86%), ofloxacin (42.86%), and gentamicin (48.86%); 16% Escherichia coli were resistant to amikacin and 4% to meropenem. P. aeruginosa showed 7.69% were resistant to amikacin and 0% to Amikacin; Amikacin resistance in K. pneumoniae was 14.29% and 0 for meropenem.Conclusions:The pathogenic bacteria in patients with skin and soft tissue infection are often Gram-positive, and there are different resistance phenomena to various antimicrobial drugs. In clinical use, antibiotics should be rationally selected combined with the results of drug sensitivity test to reduce the bacterial drug resistance.
