Systemic sclerosis with co-infection by Salmonella Michigan ST2065: a case report

VernacularTitle:确诊系统性硬化症病例合并感染密执安沙门菌ST2065
Author: Min ZHU ¹ ; Yue LIU ; Yu XU ; Yu CHEN ; Hong LIU ; Xuebin XU
Author Information

1. 复旦大学附属华山医院检验医学科，上海200040
Keywords: Diarrhea; Salmonella; Genome; Database
From: Chinese Journal of Laboratory Medicine 2024;47(9):1079-1081
CountryChina
Language:Chinese
Abstract: A 57-year-old male patient was admitted to Shanghai Huashan Hospital due to recurrent systemic sclerosis in May 2023. The patient presented with mild diarrhea (2-3 times per day) and was suspected of having concurrent infectious diarrhea. Fecal samples, after selective enrichment and isolation, identified a'non-A-F serogroup Salmonella′. Salmonella Michigan ST2065 was identified in the reference laboratory by serotyping, drug resistance phenotyping, whole genome sequencing and cross-referencing with the regional serotype database of Salmonella in China. Combined with drug resistance and virulence results, the strain was determined to exhibit a phenotype characterized by high drug resistance and low enterotoxin production. The patient was prescribed oral tigecycline for 7 days and was discharged with improved symptoms.