BF-7 Improved Memory Function and Protected Neuron from Oxidative Stress.
10.11637/kjpa.2004.17.4.313
- Author:
Moo Yeol LEE
1
;
Sang Hyung LEE
;
Jung Sang LEE
;
Kyung Joon MIN
;
Kwang Gill LEE
;
Joo Hong YEO
;
Hye Jin KWON
;
Jeong Kyu LEE
;
Yong Koo KANG
;
Do Yeon LEE
;
Yoon Hee CHUNG
;
Kyung Yong KIM
;
Sung Su KIM
;
Won Bok LEE
Author Information
1. Department of Anatomy, College of Medicine, Chung Ang University, Korea. whitefox@cau.ac.kr
- Publication Type:Original Article
- Keywords:
Memory;
Cognitive function;
BF-7;
Oxidative stress;
K-WAIS;
Apoptosis
- MeSH:
Adult;
Apoptosis;
Bombyx;
Brain;
Cognition;
Humans;
Memory*;
Nervous System;
Neurons*;
Oxidative Stress*;
Reactive Oxygen Species
- From:Korean Journal of Physical Anthropology
2004;17(4):313-320
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Endogenously or exogenously generated oxidative stress impair organs, especially brain. Also, the oxidative stress appears to be a negative factor on normal brain function, like memory and cognition. Our result showed that BF-7, extracted from Bombyx mori, effectively diminished oxidative stress, leading to the protection of neuron from reactive oxygen species donated by FeSO4 . Clinical experiments showed that BF-7 significantly improved memory and cognitive functions of normal adults in a dose-dependent manner. Thus, our results suggest that BF-7 play a role in the improvement of brain functions by removing oxidative stress, and provide therapeutic potential role of BF-7 to protect nervous system from oxidative damage.
