Clinical characteristics of newly-developed lesions of early esophageal cancer and precancerous lesions after endoscopic submucosal dissection
10.3760/cma.j.cn321463-20240121-00320
- VernacularTitle:食管早期癌及癌前病变内镜黏膜下剥离术后新发病灶的临床特征分析
- Author:
Chenyang JIAO
1
;
Yun QIAN
;
Yujiang LI
;
Bin YANG
;
Yiwei FU
Author Information
1. 南京医科大学附属泰州人民医院消化内科，泰州 225300
- Keywords:
Esophageal neoplasms;
Early diagnosis;
Risk factors;
Metachronous multiple primary esophageal cancer;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2024;41(10):782-786
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the clinical characteristics of newly-developed lesions of early esophageal cancer and precancerous lesions after endoscopic submucosal dissection (ESD) , and to investigate the risk factors associated with metachronous multiple primary early esophageal cancers.Methods:A retrospective analysis was conducted on clinical data and postoperative follow-up results of 311 patients who underwent esophageal ESD at the Department of Gastroenterology, Taizhou People's Hospital, from January 2018 to January 2020. The incidence and interval of newly-developed lesions were documented, and the risk factors for metachronous multiple primary esophageal cancers were identified.Results:Among the 311 patients, 1 case (0.3%) experienced local recurrence, 2 patients (0.6%) had synchronous multiple primary early esophageal cancers, and 27 cases (8.7%) had metachronous multiple primary early esophageal cancers. Multivariate regression analysis showed that lesion length ( OR=5.728, 95% CI: 0.959-34.208, P<0.001), Lugol-voiding lesions (LVLs) with speckled distribution ( OR=6.574, 95% CI: 2.163-19.977, P<0.001), and high neutrophil-to-lymphocyte ratio (NLR) ( OR=3.72, 95% CI: 2.144-6.452, P<0.001) were independent risk factors for metachronous multiple primary early esophageal cancers. Conclusion:Incidence of metachronous multiple primary early esophageal cancers is elevated in patients with long lesions, LVLs exhibiting speckled distribution, and high NLR. Therefore, close follow-up is essential for patients displaying these identified risk factors.
