Research progress in the characterization and detection methods of OXA-48-like carbapenemase in Enterobacteriaceae
10.3760/cma.j.cn112309-20231130-00161
- VernacularTitle:肠杆菌科细菌中OXA-48-like碳青霉烯酶特征及检测方法研究进展
- Author:
Pingping HUANG
1
;
Jun YUAN
Author Information
1. 贵州医科大学检验学院，贵阳 550004
- Keywords:
Carbapenem-resistant enterobacterales;
Carbapenemases;
Oxacillinase-48-like
- From:
Chinese Journal of Microbiology and Immunology
2024;44(11):999-1004
- CountryChina
- Language:Chinese
-
Abstract:
Carbapenem-resistant enterobacteriaceae(CRE), also known as "super bacteria", has been emerging for several years as a major public-health concern worldwide. The production of carbapenemases is the most crucial resistance mechanism in CRE. The genes encoding carbapenemases can be transmitted by via plasmids, representing a primary cause of nosocomial infections and the widespread proliferation of antibiotic resistance. Carbapenemases, particularly the class A β-lactamases, have long been considered the most crucial resistance mechanism. However, the stealthy dissemination of OXA-48-like carbapenemases presents a more significant threat. OXA-48-like carbapenemases family members have complex composition, with variable hydrolytic activities against β-lactam drugs. They generally demonstrate weaker hydrolytic activity against carbapenems, leading to challenges in detection, which pose significant obstacles in clinical diagnosis, treatment, infection control. Therefore, this review focuses on the OXA-48-like carbapenemases family composition, epidemiology, hydrolytic activity, crystal structure, transmission mode and detection method.
