Research progress in clinical epidemiology and β-lactam resistance mechanism of Proteus mirabilis
10.3760/cma.j.cn112309-20231102-00119
- VernacularTitle:奇异变形杆菌的临床流行病学和β-内酰胺类药物耐药机制研究进展
- Author:
Binyao ZHANG
1
;
Ruirui MA
;
Yingchun XU
;
Yali LIU
Author Information
1. 中国医学科学院北京协和医学院北京协和医院检验科，北京 100730
- Keywords:
Proteus mirabilis;
Urinary tract infections;
Bloodstream infection;
β-lactamases;
Resistance mechanism
- From:
Chinese Journal of Microbiology and Immunology
2024;44(10):906-911
- CountryChina
- Language:Chinese
-
Abstract:
Proteus mirabilis is a gram-negative rod-shaped bacterium that can cause urinary tract infections, bloodstream infections and gastrointestinal infections. Urinary tract infections caused by Proteus mirabilis are hard to be treated and pose a serious public health problem. With the use of antimicrobial drugs for clinical treatment, the resistance rates of Proteus mirabilis to β-lactams and quinolones increase. Besides the unregulated use of antimicrobial drugs contributes to the emergence of multidrug-resistant Proteus mirabilis and carbapenem-resistant Proteus mirabilis. In this review, we will discuss Proteus mirabilis-related clinical infections, and the epidemiological characteristics and β-lactam resistance mechanism, hoping to provide ideas for the treatment and prevention of Proteus mirabilis infections in the future.
