Research progress on the relationship between vaginal microbiota and premature cervical remodeling
10.3760/cma.j.cn113903-20240304-00180
- VernacularTitle:阴道微生物菌群与宫颈提前重构研究进展
- Author:
Xinyi WANG
1
;
Chunyan SHI
;
Huixia YANG
Author Information
1. 北京大学第一医院妇产生殖医学中心，北京 100034
- Keywords:
Vaginal microbiota;
Cervical remodeling;
Preterm birth
- From:
Chinese Journal of Perinatal Medicine
2024;27(7):588-594
- CountryChina
- Language:Chinese
-
Abstract:
Preterm birth is the primary cause of neonatal morbidity and mortality in infants under five years of age. Research into its underlying causes and mechanisms is crucial. Preterm birth is a consequence originating from various factors. The etiology can be asynchronous activation of the uterine wall, the choriodecidua, and the cervix, but the phenotype that initiates in the choriodecidua and myometrium also ultimately presents as shortening and softening of the cervix. The initiation of the Human Microbiome Project shed light on more in-depth studies regarding the composition of microbiota in various parts of the human body and its relationship to health. Among these investigations, some progress was achieved on the pregnancy-related vaginal microbiota and dysbiosis, and pathological pregnancies. Based on previous achievements, this article reviews the latest literature discussing the relationship between vaginal microbiota and premature cervical remodeling and the involved mechanisms, seeking to identify unresolved topics in this area, as well as novel preventive and therapeutic strategies.
