A case of anti-glomerular basement membrane nephritis complicated with anti-neutrophil cytoplasmic antibody associated vasculitis and IgA nephropathy
10.3760/cma.j.cn441217-20230712-00707
- VernacularTitle:抗肾小球基底膜肾炎合并抗中性粒细胞胞质抗体相关性血管炎和IgA肾病1例
- Author:
Lihua LUO
1
;
Yujuan YANG
;
Zhiping ZHANG
;
Jikong MA
;
Huaying ZHANG
Author Information
1. 大理白族自治州人民医院肾内科，大理白族自治州 671000
- Keywords:
Anti-glomerular basement membrane disease;
Antibodies, antineutrophil cytoplasmic;
Glomerulonephritis, IgA;
Acute progressive glomerulonephritis
- From:
Chinese Journal of Nephrology
2024;40(5):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Anti-glomerular basement membrane (GBM) nephritis and anti-neutrophil cytoplasmic antibody (ANCA) -associated vasculitis are both autoimmune diseases that can involve multiple systems throughout the body, and both can cause crescent glomerulonephritis. At present, cases of such "double-positive" antibodies have been reported at home and abroad , but the cases of acute progressive glomerulonephritis (RPGN) with IgA nephropathy that are both positive for GBM and ANCA are relatively rare. This case was a middle-aged female patient, whose clinical manifestations were consistent with rapidly progressive glomerulonephritis, positive for anti-GBM antibodies and anti-myeloperoxidase. After renal puncture biopsy, she was diagnosed as anti-GBM nephritis complicated with ANCA associated vasculitis and IgA nephropathy.After treatment with plasma exchange, hemodialysis, glucocorticoids, cyclophosphamide, etc., the condition improved and the patient was discharged. But the patient did not follow the doctor's instructions to take medication and continue hemodialysis treatment after discharge, and the condition worsened, ultimately leading to death.
