Recent advance in molecular biomarkers of Alzheimer's disease associated with vascular senescence

VernacularTitle:血管衰老相关的阿尔茨海默病生物标志物研究进展
Author: Rui WEN ¹ ; Chunming XIE
Author Information

1. 东南大学医学院，南京　210009
Keywords: Alzheimer's disease; Vascular aging; Biomarker
From: Chinese Journal of Neuromedicine 2024;23(9):933-939
CountryChina
Language:Chinese
Abstract: Alzheimer's disease (AD) is the most common type of dementia. At present, its accurate diagnosis is mainly based on positron emission tomography (PET) or detection of β-amyloid plaque and tau protein in cerebrospinal fluid. However, due to the expensiveness and radioactive problems of PET, the acquisition of cerebrospinal fluid requires invasive lumbar puncture, which obviously limits the accurate diagnosis of AD in clinical practice. Recent studies have increasingly indicated that vascular aging is involved in AD pathogenesis and may represent a notable clinical feature during the prodromal stage. This article reviews the roles of various molecules associated with pathophysiological mechanisms of vascular aging, such as leukocyte telomere length, platelet-derived growth factor receptor-β, fibrinogen-1, and inflammatory factors (cell adhesion molecules, matrix metalloproteinases and cmonocyte chemotactic protein-1) in AD development, as observed in recent animal and clinical studies, so as to find new biomarkers or therapeutic targets for precise diagnosis and treatment of AD.