Recent advance in DTI-ALPS in evaluating cerebral glymphatic system and cerebral small vascular disease
10.3760/cma.j.cn115354-20240717-00420
- VernacularTitle:DTI-ALPS技术在脑类淋巴系统及脑小血管病评估中的研究进展
- Author:
Xue ZHANG
1
;
Min ZHANG
;
Wenwei YUN
Author Information
1. 南京医科大学附属常州第二人民医院（南京医科大学常州医学中心）神经内科，常州 213000
- Keywords:
Glymphatic system;
Diffusion tensor image analysis along the perivascular space;
Cerebral small vessel disease;
Neuroimaging biomarker;
Cognitive impairme
- From:
Chinese Journal of Neuromedicine
2024;23(8):854-858
- CountryChina
- Language:Chinese
-
Abstract:
Glymphatic system (GS), also known as glial-lymphatic system, plays a vital role in maintaining brain homeostasis. Previous research has established a link between cerebral small vessel disease (CSVD) and GS dysfunction. Diffusion tensor image analysis along the perivascular space (DTI-ALPS), an emerging non-invasive neuroimaging technique, has made significant strides in assessing GS function in central nervous system diseases. This review examines the DTI-ALPS principles, and relations of DTI-ALPS index with glymphatic circulation, various imaging markers of CSVD, and CSVD-related cognitive impairment, aiming to facilitate the early diagnosis, progression, and prognoses of CSVD.
