Recent advance in role of c-abl kinase in pathogenesis and treatment of Alzheimer's disease
10.3760/cma.j.cn115354-20240318-00171
- VernacularTitle:c-abl激酶在阿尔茨海默病发病及治疗中的作用研究进展
- Author:
Xiangheng TANG
1
;
Xiaoqin ZHUO
;
Huayucheng TANG
;
Jing HU
Author Information
1. 重庆医科大学第一临床学院，重庆 400016
- Keywords:
Alzheimer's disease;
C-abl kinase;
Tyrosine kinase inhibitor
- From:
Chinese Journal of Neuromedicine
2024;23(7):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system, seriously threatening the health and development of human beings. AD pathogenesis is related to amyloid β-protein accumulation, microtubule-associated protein Tau accumulation and hyperphosphorylation in the brain. C-abl kinase can affect signal pathways related to Aβ and Tau proteins, promote neuroinflammatory response and respond to oxidative stress signals; and its overexpression can lead to neuronal damage, resulting in clinical manifestations such as cognitive and memory decline. This paper reviews the relationship between c-abl kinase and AD pathogenesis, and feasibility and limitations of c-abl kinase inhibitors in AD, in order to provide new ideas for AD treatment.
