Clinical analysis of brain death determination in organ donors under veno-arterial extracorporeal membrane oxygenation assisted circulatory support
10.3760/cma.j.cn115354-20240417-00241
- VernacularTitle:静脉-动脉体外膜氧合支持下器官捐献供体脑死亡判定的临床分析
- Author:
Songying SHEN
1
;
Meiyun JIA
;
Hong WANG
;
Yunfeng ZHAO
;
Huijun DONG
;
He ZHAO
;
Wei QIN
;
Xingsong QIN
;
Meng ZHAO
;
Yajie LIU
;
Hongyu WANG
Author Information
1. 河南中医药大学人民医院/郑州人民医院器官移植中心，郑州 450000
- Keywords:
Extracorporeal membrane oxygenation;
Organ donation;
Brain death;
Apnea test;
Donor
- From:
Chinese Journal of Neuromedicine
2024;23(4):392-396
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the experience of brain death determination under veno-arterial extracorporeal membrane oxygenation (VA-ECMO) assisted circulatory support, especially apnea test (AT) precautions, and to provide references for brain death determination in this scenario.Methods:In 78 patients who had VA-ECMO at Organ Transplant Center, Zhengzhou People's Hospital from October 2019 to December 2023, 8 organ donors had brain death determination under VA-ECMO assisted circulatory support. Baseline data, clinical data, and VA-ECMO data during AT trial were collected from these 8 patients to summarize the process of brain death determination.Results:Six of the 8 donors met the criteria of brain death; 10 EEG, 12 evoked potentials and 15 ATs were performed. Complications in ATs, including hypotension, decreased oxygenation and arrhythmia, were alleviated after timely improved VA-ECMO flow and applied cardiotonic and pressor drugs.Conclusion:AT is key for successful brain death determination in organ donors under VA-ECMO assisted circulatory support; therefore, complications should be closely monitored and managed.
