Progress in the relationship between different dietary patterns and Alzheimer′s disease and related mechanism
10.3760/cma.j.cn113694-20240411-00226
- VernacularTitle:不同饮食模式与阿尔茨海默病的关系及其机制进展
- Author:
Mingyue HE
1
;
Dongmei LUO
;
Wei ZHANG
Author Information
1. 首都医科大学附属北京天坛医院神经病学中心，北京100070
- Keywords:
Alzheimer disease;
Food habits;
Cognition;
Inflammation;
Oxidative stress;
Tau proteins;
Amyloid
- From:
Chinese Journal of Neurology
2024;57(11):1281-1289
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer′s disease (AD) is the most common type of cognitive impairment, characterized by complex pathology and pathogenesis. Regrettably, the effective therapeutic approaches remain unfulfilled, underscoring the pressing need to explore innovative preventive and therapeutic avenues. Research has illuminated the potential of intervening in risk factors and modifying lifestyle choices to diminish the incidence and decelerate the progression of AD. Notably, dietary patterns, such as Mediterranean diet, ketogenic diet, and calorie restriction have emerged as promising candidates for bolstering cognitive function in AD patients. These dietary approaches achieve this by multiple mechanisms, including mitigating the accumulation of neuropathological proteins, curbing neuroinflammation and oxidative stress, fortifying autophagy, and enhancing synaptic plasticity, etc. These findings strongly suggest that dietary intervention harbors the potential to serve as a novel and viable therapeutic strategy for AD. This review summarized the effects of different dietary patterns on the occurrence, progression, pathology and mechanism of AD.
