Advantages and challenges of brain organoid modeling for genetic diseases of the nervous system
10.3760/cma.j.cn113694-20231226-00404
- VernacularTitle:神经系统遗传疾病脑类器官模型构建的优势与挑战
- Author:
Siqi HUANG
1
;
Yinghong YANG
;
Xiaofang SUN
;
Yingjun XIE
Author Information
1. 广州医科大学附属第三医院妇产科实验部科研平台 广东省产科重大疾病重点实验室 广东省妇产疾病临床医学研究中心 粤港澳母胎医学高校联合实验室，广州 510150
- Keywords:
Brain organoids;
Neurogenetic diseases;
Induced pluripotent stem cells;
Disease model
- From:
Chinese Journal of Neurology
2024;57(9):1030-1036
- CountryChina
- Language:Chinese
-
Abstract:
Brain organoids are self-organized 3D aggregates generated by human embryonic stem cells or human induced pluripotent stem cells. Their cell type and structure are similar to embryonic human brain, which are good in vitro models for the study of neurogenetic diseases and have been widely used in the study of neurogenetic diseases. This paper will discuss the advantages and challenges of brain organoids in the modeling of genetic diseases of the nervous system.
