Treatment of drug resistant epilepsy
10.3760/cma.j.cn113694-20240622-00427
- VernacularTitle:耐药性癫痫的治疗
- Author:
Suiqiang ZHU
1
;
Shanshan HUANG
Author Information
1. 华中科技大学同济医学院附属同济医院神经内科，武汉430030
- Keywords:
Epilepsy;
Drug resistant epilepsy;
Antiseizure medication;
Treatment
- From:
Chinese Journal of Neurology
2024;57(9):931-935
- CountryChina
- Language:Chinese
-
Abstract:
It is estimated that approximately one-third of epilepsy patients are affected by drug resistance. After 2 appropriately used antiseizure medications have failed to control seizures, patients should be referred to a comprehensive epilepsy center for re-evaluation and targeted treatment whenever possible. Patients with a clear cause should receive treatment targeted at the cause of epilepsy; patients without a clear cause should consider the feasibility of epilepsy surgery and other treatments as early as possible. Substantial evidence shows that delaying the effective treatment may adversely affect the clinical outcomes and increase the risk of cognitive impairment, other comorbidities, and premature death. Research on the mechanisms of drug resistance and new drug development in epilepsy is progressing rapidly, and new treatment methods, including disease-modifying therapies, are promising.
