Role of B lymphocyte stimulator/a proliferation-inducing ligand in neuroimmune diseases

VernacularTitle:B淋巴细胞刺激因子和增殖诱导配体在神经免疫性疾病中的作用
Author: Jie DING ¹ ; Yangtai GUAN
Author Information

1. 上海交通大学医学院附属仁济医院神经内科，上海　200127
Keywords: B-cell activating factor; A proliferation-inducing ligand; Neuroimmune diseases; Pathogenesis; Neuromyelitis optica spectrum disorders
From: Chinese Journal of Neurology 2024;57(6):661-669
CountryChina
Language:Chinese
Abstract: B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), both members of the tumor necrosis factor superfamily, share strong homology. As lymphocyte co-stimulators, BLyS/APRIL can regulate a variety of biological functions, including cell differentiation, proliferation, survival, and especially regulate immune functions of B cells and T cells. BLyS/APRIL plays an important role in the occurrence and development of neuroimmune diseases such as neuromyelitis optica spectrum disorders, multiple sclerosis and myasthenia gravis. This paper aims to improve the understanding of BLyS/APRIL and its role in neuroimmune diseases.