Association of triglyceride glucose index and its combination with body mass index with non-alcoholic fatty liver disease among medical workers
10.3760/cma.j.cn114798-20240910-00743
- VernacularTitle:医务人员群体甘油三酯葡萄糖指数及其联合体重指数与非酒精性脂肪肝的关联分析
- Author:
Yanping FENG
1
;
Yuexia ZHANG
;
Di CHEN
Author Information
1. 首都医科大学附属北京积水潭医院社区医学科，北京102208
- Keywords:
Fatty liver;
Triglyceride glucose index;
Body mass index;
Medical staff
- From:
Chinese Journal of General Practitioners
2024;23(11):1168-1173
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association of triglyceride glucose (TyG) index and its combination with body mass index (TyG-BMI) with non-alcoholic fatty liver disease (NAFLD) among medical workers.Method:A total of 1 642 medical workers in Beijing Jishuitan Hospital with the age of 36.0 (31.0, 44.0) years and 394 males (24.00%) underwent health check-up in the hospital from January to December 2022. Among them, NAFLD was diagnosed in 377 subjects (NAFLD group) and 1 265 had no NAFLD (control group). The anthrometric and clinical data were collected, including age, gender, height, weight, systolic blood pressure, diastolic blood pressure, laboratory test indicators, imaging findings, current and past medical history, long-term medication history, alcohol consumption history, etc. The factors associated NAFLD were analyzed with multivariate logistic regression model, the diagnostic value of TyG index and TyG-BMI for NAFLD was evaluated with receiver operating characteristic (ROC) curve.Results:Multivariate logistic regression analysis showed that TyG index ( OR=3.534, 95% CI: 2.383-5.243, P<0.001) and TyG-BMI ( OR=1.041, 95 CI:1.033-1.048, P<0.001) were independently correlated with NAFLD. ROC curve analysis showed that the area under the curve ( AUC) of TyG-BMI in diagnosis of NAFLD was 0.906 (95% CI:0.890-0.922), with a sensitivity and specificity of 85.7% and 81.6%, respectively; while the AUC of TyG index was 0.845 (95% CI:0.823-0.867) with a sensitivity and specificity of 69.8% and 84.1%, respectively. The AUC of TyG-BMI in female medical workers (0.911, 95% CI:0.892-0.931) was higher than that of male ones (0.852, 95% CI:0.815-0.890); the AUC of TyG index of female medical workers (0.832, 95% CI:0.801-0.863) was also higher than that in male ones (0.804, 95% CI:0.761-0.846). Conclusion:The prevalence of NAFLD among medical worker is associated with the TyG and TyG-BMI, and TyG-BMI has higher diagnostic value for NAFLD, especially among female medical workers.
