Paradoxical psoriasis induced by tumor necrosis factor-α inhibitors and other biological agents
- VernacularTitle:肿瘤坏死因子α抑制剂及其他生物制剂相关矛盾性银屑病的临床研究进展
- Author:
Jiawei LU
1
;
Yan LU
Author Information
- Keywords: Psoriasis; Tumor necrosis factor-alpha; Biological agents; Drug toxicity; Paradoxical psoriasis
- From: Chinese Journal of Dermatology 2024;57(5):479-482
- CountryChina
- Language:Chinese
- Abstract: Tumor necrosis factor (TNF) -α inhibitors have become an important choice for patients with chronic inflammatory diseases who are intolerant or poorly responsive to conventional therapies. Studies have shown that psoriasis can develop or be exacerbated in 2% - 5% of patients treated with TNF-α inhibitors, and this phenomenon is called paradoxical psoriasis. Paradoxical psoriasis and classic psoriasis have similar clinical manifestations, but different immunological mechanisms. This review summarizes the pathogenesis, clinicopathological features and management of paradoxical psoriasis, and provides an overview of paradoxical psoriasis following the application of other common biological agents.
