Chemical constituents from Lonicera japonica and their antioxidant activities
10.3969/j.issn.1001-1528.2024.08.024
- VernacularTitle:金银花化学成分及其抗氧化活性研究
- Author:
Yuan LU
1
;
Yan ZHANG
;
Ying WANG
;
Jia-Xuan DONG
;
Bao-Yu DU
;
Yong-Qing ZHANG
;
Ran YANG
Author Information
1. 山东中医药大学药学院,山东 济南 250355
- Keywords:
Lonicera japonica Thunb.;
chemical constituents;
isolation and identification;
antioxidant activities
- From:
Chinese Traditional Patent Medicine
2024;46(8):2638-2644
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Lonicera japonica Thunb.and their antioxidant activities.METHODS The extract from L.japonica was isolated and purified by D101 macroporous resin,silica gel column and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The antioxidant activity was determined by DPPH free radical scavenging method.RESULTS Fifteen compounds were isolated and identified as dearabinosyl pneumonanthoside(1),5α-carboxystrictosidine(2),apigenin 7-O-glucoside(3),ethyl caffeate(4),isorhamnetin-3-O-β-D-glucopyranoside(5),luteolin 7-O-glucoside(6),quercetin 3-O-β-glucoside(7),luteolin 7-O-rutinoside(8),luteolin-7-O-neohesperidoside(9),hydnocarpin(10),methyl chlorogenate(11),(Z)-aldosecolohanin(12),kaempferol 3-O-β-D-glucoside(13),chlorogenic acid butyl ester(14),(-)-syringaresinol(15).The IC50 values of DPPH free radical scavenging of compounds 3,5-10,13-14 were 6.70-36.25 μmol/L.CONCLUSION Compounds 1-2,8,9-11 and 15 are isolated from genus Lonicera for the first time.Compounds 3,5-10,13-14 show good antioxidant activities.
