Clinical effects of Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction on patients with ulcerative colitis due to Spleen Deficiency with Dampness-Heat
10.3969/j.issn.1001-1528.2024.06.014
- VernacularTitle:参苓薏苡三七方联合止血生肌汤灌肠对脾虚湿热证溃疡性结肠炎患者的临床疗效
- Author:
Yi CHANG
1
;
Ying-Jun LIU
;
Hui JIN
Author Information
1. 鞍山市中医院中医内科,辽宁鞍山 114006
- Keywords:
Shenling Yiyi Sanqi Formula;
Zhixue Shengji Decoction;
enema;
ulcerative colitis;
Spleen Deficiency with Dampness-Heat
- From:
Chinese Traditional Patent Medicine
2024;46(6):1862-1866
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction on patients with ulcerative colitis due to Spleen Deficiency with Damp-Heat.METHODS One hundred and fourteen patients were randomly assigned into control group(57 cases)for 4-week intervention of enema of Zhixue Shengji Decoction,and observation group(57 cases)for 4-week intervention of both Shenling Yiyi Sanqi Formula and enema of Zhixue Shengji Decoction.The changes in clinical effects,TCM syndrome scores,Baron endoscopic score,modified Mayo score,VAS score,intestinal flora(Enterococcus,Lactobacillus,Enterobacterium,Bifidobacterium),correlation factors(FCP,ESR,IL-10,TNF-α,TLR4,PGE2),intestinal barrier function factors(L/M,DAO,D-lactic acid)and safety indices were detected.RESULTS The observation group demonstrated higher complete remission rate and total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,Baron endoscopic score,modified Mayo score,VAS score,FCP,ESR,TNF-α,TLR4,PGE2,intestinal barrier function factors(P＜0.05),increased IL-10(P＜0.05),reduced Enterococcus,Enterobacterium,and enhanced Lactobacillus,Bifidobacterium(P＜0.05),especially for the observation group(except for Enterococcus)(P＜0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with ulcerative colitis due to Spleen Deficiency with Dampness-Heat,Shenling Yiyi Sanqi Formula combined with enema of Zhixue Shengji Decoction can safely and effectively regulate intestinal flora,improve intestinal barrier function,and enhance analgesic,anti-inflammatory effects.
