Influence of hypertension and antihypertensive drugs on erectile dysfunction and the underlying mechanism:An update

VernacularTitle:高血压与抗高血压药物对勃起功能障碍的影响及机制的研究进展
Author: Hong-Ming FENG ¹ ; Shuai LIU ; Qiang FU
Author Information

1. 山东第一医科大学附属省立医院泌尿外科,山东济南 250021
Keywords: erectile dysfunction; hypertension; antihypertensive drug; comorbidity mechanism
From: National Journal of Andrology 2024;30(11):1036-1042
CountryChina
Language:Chinese
Abstract: Hypertension is a most common chronic disease and a most important risk factor for cardiovascular and cerebrovascu-lar diseases,and is also closely related to the development and progression of erectile dysfunction(ED).Existing evidence shows that hypertension is a risk factor for ED due to comorbidities.ED can also be regarded as the"message tree"of cardiovascular diseases.During hypertension,pro-vasoconstrictor factors,such as aldosterone,norepinephrine,and ET-1,break the balance between vasocon-striction and vasodilation,and consequently affect vascular and erectile function.Furthermore,relevant studies have confirmed the in-fluence of various antihypertensive drugs on erectile function,either positively or negatively.This review summarizes the findings in the relevant studies over the past five years,focusing on the effects of hypertension and antihypertensive drugs on erectile function and the specific underlying mechanisms.