Spouse smoking cessation benefits the pregnancy outcomes of the women with polycystic ovary syndrome
10.13263/j.cnki.nja.2024.11.005
- VernacularTitle:丈夫戒烟行为对多囊卵巢综合征患者孕产结局的影响
- Author:
Meng-Yi ZHU
1
;
Jia-Xing FENG
;
Yang LIU
;
Jing-Shu GAO
;
Yu WANG
;
Xiao-Ke WU
Author Information
1. 黑龙江中医药大学研究生院,黑龙江哈尔滨 150040
- Keywords:
polycystic ovary syndrome;
husband;
smoking cessation;
pregnancy outcome;
secondary analysis
- From:
National Journal of Andrology
2024;30(11):994-1001
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of spouse smoking cessation(SSC)on the pregnancy outcome of the patients with polycystic ovary syndrome(PCOS)based on a secondary analysis of the results of a large randomized clinical trial.Methods:Basedon the inclusion and exclusion criteria,this secondary analysis included 861 female participants in the Trial of Acu-puncture Combined with Clomiphene for PCOS from 2011 to 2015.According to the smoking status of their husbands,we divided the subjects into a smoking group(n=345),a non-smoking group(n=387),and a smoking cessation group(n=129),collected their general demographics,anthropometric indexes,laboratory results and pregnancy outcomes,compared them among the three groups,and analyzed the relationship of SSC with the pregnancy outcomes of the PCOS patients.Results:The levels of total testos-terone(T)and low-density lipoprotein cholesterol(LDL-C)in the smoking cessation group were similar to those in the non-smoking group,but significantly lower than those in the smoking group(P=0.014 and P=0.011).The contents of fasting insulin,total cho-lesterol,and apolipoprotein B exhibited statistically significant differences among the three groups(P=0.029,P=0.018 and P=0.024),dramatically lower in the smoking cessation and non-smoking groups than in the smoking group,but similar between the for-mer two.The ovulation rate of the smoking cessation group was similar to that of the non-smoking group,remarkably higher than that of the smoking group(P=0.038).No statistically significant differences were observed in other indicators among the three groups(P＞0.05).Multivariate logistic regression analysis showed that SSC during pregnancy preparation was a protective factor for ovulation in the PCOS patients(OR=1.74,95％CI:1.04-2.92,P=0.035).Conclusion:SSC can improve androgen and glucolipid me-tabolisms of infertile patients with PCOS,and thereby significantly increase the ovulation rate.It is of positive significance to encourage SSC clinically for improving the pregnancy outcomes of infertile women with PCOS.
