Traditional Chinese medicine to treat oligoasthenozoospermia by regulating cellular autophagy

VernacularTitle:中医药调控细胞自噬治疗少弱精子症研究进展
Author: Jin DING ¹ ; Xu-Yun WANG ; Qing-Hu HE ; Xing ZHOU
Author Information

1. 广州中医药大学第七临床医学院/深圳市宝安区中医院,广东深圳 518133
Keywords: oligoasthenozoospermia; spermatogenesis and maturation; cellular autophagy; Traditional Chinese Medicine; re-search progress
From: National Journal of Andrology 2024;30(9):832-840
CountryChina
Language:Chinese
Abstract: Oligoasthenozoospermia(OAS)is the main factor for male infertility,and the cause and pathogenesis of the disease remain unknown.Emerging data indicate that cellular autophagy is closely correlated with male reproduction,especially the biosynthet-ic and catabolic processes of spermatogenesis and sperm maturation.Nonetheless,it is not yet clear whether autophagy plays a protec-tive or a harmful role in these processes.Traditional Chinese medicine(TCM)has exhibited a definite therapeutic effect on OAS,and its action mechanism might be closely associated with cellular autophogy,and its related markers and pathways.This article systemati-cally reviews the role of cellular autophagy in spermatogenesis and sperm maturation,as well as the therapeutic effect of TCM on OAS by regulating the process of autophagy,aiming to gain a deeper insight into the potential mechanism of TCM acting on OAS and provide some references for further improvement of its clinical efficacy.