Mitochondrial damage and male reproductive dysfunction:Progress in research
10.13263/j.cnki.nja.2024.08.012
- VernacularTitle:线粒体损伤与男性生殖功能障碍的研究进展
- Author:
Jin-Dong LI
1
;
Zhen-Xiang LIU
;
Xue-Jun SHANG
Author Information
1. 南方医科大学南京临床医学院/东部战区总医院泌尿外科,江苏南京 210002;中南大学湘雅医学院附属海口医院泌尿外科,海南海口 570100
- Keywords:
mitochondria;
sperm;
male infertility;
reactive oxygen species;
apoptosis;
mitochondrial DNA;
mitochondrial fu-sion/division
- From:
National Journal of Andrology
2024;30(8):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are the center of sperm metabolism and essential for all aspects of flagellar motility,capacitation,acro-some reaction and gametic fusion of sperm.Abnormalities in the mitochondrial ultrastructure,membrane potential,reactive oxygen spe-cies,Ca2+homoeostasis,sperm apoptosis,mitochondrial DNA,mitochondrial enzymes and proteomic activity can decrease sperm quality and even cause male infertility.This paper elucidates the impact of mitochondrial dysfunction on sperm by reviewing and analy-zing relevant literature on mitochondria and male reproductive function,aiming to provide some theoretical evidence for exploring effec-tive interventions for male reproductive dysfunction.
