Ferroptosis in male reproductive system diseases:Progress in research
10.13263/j.cnki.nja.2024.02.014
- VernacularTitle:铁死亡在男性生殖系统疾病中的研究进展
- Author:
A-Jian PENG
1
;
Xue TANG
;
Gu-Fen JIANG
;
Xing ZHOU
Author Information
1. 湖南中医药大学第一中医临床学院,湖南长沙 410007;湖南中医药大学第一附属医院,湖南长沙 410007
- Keywords:
ferroptosis;
iron metabolism;
GPX4;
lipid peroxidation;
male reproduction
- From:
National Journal of Andrology
2024;30(2):174-179
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is an iron-dependent form of programmed cell death triggered by the excessive accumulation of lipid peroxides on the cell membrane.Recent studies have found that ferroptosis can be induced by exposure of the testis tissue and germ cells to some high-risk factors,accompanied by various characteristic reproductive system injuries,including changes in cell morphology,ferroptosis-related physico-chemical indicators and gene expressions.This review focuses on the association of ferroptosis with male reproductive system diseases from three key aspects:iron metabolism abnormalities,Cystine/GSH/GPX4 axis imbalance,and lipid peroxidation.
