Resveratrol enhances the local antioxidant ability of the ovary in rats with polycystic ovary syndrome
10.13263/j.cnki.nja.2024.02.009
- VernacularTitle:白藜芦醇提高多囊卵巢综合征大鼠卵巢局部抗氧化水平的研究
- Author:
Tao SHEN
1
;
Yuan-Jiao LIANG
;
Xia ZHAO
;
Su LU
Author Information
1. 南京中医药大学第一临床医学院,江苏南京 210004;东南大学附属中大医院生殖医学科,江苏南京 210004
- Keywords:
anti-Müllerian hormone;
glutathione peroxidase;
polycystic ovary syndrome;
resveratrol;
superoxide dismutase
- From:
National Journal of Andrology
2024;30(2):145-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of resveratrol(RSV)on ovarian morphology,plasma anti-Müllerian hormone(AMH)and insulin-like growth factor 1 levels(IGF-1),and oxidative stress parameters in rats with polycystic ovary syndrome(PCOS).Methods:Forty-six rats were randomly divided into a normal control(n=12),a PCOS model control(n=12),a ros-iglitazone(RSG,n=11),and an RSV group(n=11).The PCOS model was established in the latter three groups by rejection of epidehydroandrosterone.The rats in the normal control and PCOS model control groups were treated by gavage of normal saline and those in the RSG and RSV groups by intragastric administration of RSG at 10 mg/(kg·d)and RSV at 3.0 mg/(kg·d),respective-ly.After 4 weeks of treatment,the ovarian histology was observed under the light microscope,the levels of plasma AMH and IGF-1 measured by ELISA,and the activities of glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)and catalase(CAT)in the ovarian tissue detected using the Ellman,Sun and AEBI methods,respectively.Results:After a4-week treatment,statistically sig-nificant differences were observed in the above indicators between the normal control and PCOS model control groups(P＜0.05).The rats treated with RSG and RSV also showed significant differences in these parameters from the model controls(P＜0.05).Conclu-sion:RSV can enhance the local antioxidant capacity of the ovary,reduce the levels of AMH and IGF-1,and improve the morphology of the ovarian tissue in rats with PCOS,indicating its potential value in the treatment of PCOS.
