Research progress on the establishment and application of the hypoxia cell model in varicocele-associated male infertility

VernacularTitle:精索静脉曲张性不育症中缺氧细胞模型的建立与应用研究进展
Author: Shu-Lin LIANG ¹ ; Ling HAN ; Shao-Ying YUAN
Author Information

1. 广州中医药大学第二临床医学院,广东广州 510006
Keywords: varicocele; infertility; hypoxia; cell model; testicular cell
From: National Journal of Andrology 2023;29(5):445-449
CountryChina
Language:Chinese
Abstract: Varicocele(VC)is considered as one of the primary causes of male infertility,and the pathogenesis and treatment measures for VC-associated male infertility(VMI)are being explored continuously.The construction of an appropriate in vitro model for VMI is of significant importance for the study of this disease.And the model of testis cell hypoxia,with its relatively stable experi-mental conditions,short cycle,good repeatability and few influencing factors,has been primarily applied in cellular experimental re-searches on VMI.This article reviews the selection of cell lines,use of modeling methods,and evaluation of cell models in recent VMI-related cellular experiments,aiming to provide some reference for scholars in their studies of the pathogenesis and treatment of VMI u-sing the in vitro experimental model.