Mechanism study of fibroblast growth factors signaling
10.3760/cma.j.cn311282-20231221-00222
- VernacularTitle:成纤维细胞生长因子信号启动机制解析
- Author:
Zhiqiang HUANG
1
;
Lili FU
;
Gaozhi CHEN
;
Xiaokun LI
Author Information
1. 温州医科大学药学院 325035
- Keywords:
Metabolic disorders;
Fibroblast growth factor;
Heparan sulfate;
Molecular mechanism
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(10):826-829
- CountryChina
- Language:Chinese
-
Abstract:
This article presents the research design and principal findings of the recent study " Structural basis for FGF hormone signalling" published in Nature. It highlights the study′s significance in elucidating the molecular mechanisms of fibroblast growth factor(FGF)23, FGF receptor(FGFR), Klotho, and heparan sulfate(HS) quaternary complex signalling. These findings offer crucial structural insights that could advance drug discovery for metabolic disorders like diabetes and chronic kidney disease.
